Study Update

Completed Studies

The Utility of Transcutaneous Bilirubin Measurement
Jim Taylor, University of Washington, served as PI for the first study conducted by the BORN network. The specific aims of the study were to: 1) Describe the distribution of TcB values in term and late preterm newborns measured in diverse settings by developing a TcB nomogram based on the data collected (BORN TcB nomogram) 2) Identify test thresholds for TcB percentiles that maximize the specificity of the screening tool while maintaining sensitivity near 100% for identification of infants with significantly elevated TSB and 3) Identify systematic sources of error in TcB measurements.

BORN Delphi Study
The objective of this study led by PI Elizabeth Simpson, University of Missouri, was to develop a consensus-based, prioritized agenda for well newborn care. A two-round modified Delphi survey of BORN members was conducted. The highest rated research questions of importance to BORN clinicians were: 1) At what weight-loss percentage is it medically necessary to formula supplement a breastfeeding infant? 2) What is the optimal management of infants with neonatal abstinence syndrome? 3) How and when should we initiate a workup for sepsis, and how should these newborns be managed?

Variation in Care of Opioid-Exposed Newborns: a BORN survey
BORN member hospitals were surveyed to identify practice variations for newborns with in-utero chronic opioid exposure. Identification of variation is the first step toward establishing best practice standards to improve care for this rapidly growing population. Deb Bogen from University of Pittsburgh, was PI for this survey.

Practice Variation in Evaluation of Term Infants at Risk for Early-Onset Sepsis
PIs Sagori Mukhopadhyay and Karen Puopolo from UPenn surveyed BORN nursery directors to determine variation in the management of newborns at risk for EOS.

Ongoing Studies

Management of Newborns with Lumbosacral Findings
This cross-sectional study of management choices made by practitioners who see newborns in a regular newborn nursury setting aims to see how much inter-observer agreement exists for management of various neonatal lumbosacral findings.

Vitamin K Refusal
As a follow-up to PI Jaspreet Loyal's, Yale University, earlier project surveying BORN nursery directors perceptions of Vitamin K refusals at their institutions, the aims of the current study are to 1) report the number of infants discharged from newborn nurseries in the BORN network who did not receive IM vitamin K and 2) describe the epidemiology of infants not receiving IM vitamin K and their mothers





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